Changes to environmental conditions as a result of natural factors and direct or indirect human activity can significantly affect the water cycle. The long-term effects of the diminution of water stocks and the short-term effects of increasingly frequent extreme events (floods and droughts) in the future are also predicted by long-term meteorological and hydrological data trends and simulations. Owing to the particular characteristics of groundwater flow and the dynamic of hydrological processes, aquifers with karst porosity are especially vulnerable to the effects of various environmental changes. Environmental changes represent both a threat and a challenge, particularly for the proper spatial development of karst-rich areas. The purpose of the project is to examine the impact of environmental changes on karst aquifers, to evaluate their vulnerability and prepare proposals for an appropriate adjustment of land use to these changes and the management of karst water sources. The key objective of the project is to develop an innovative concept of spatial planning adapted to environmental changes and management of karst water sources.