DISTENDER will provide integrated strategies by building a methodological framework that guide the integration of climate change (CC) adaptation and mitigation strategies through participatory approaches in ways that respond to the impacts and risks of climate change (CC), supported by quantitative and qualitative analysis that facilitates the understanding of interactions, synergies and tradeoffs. Holistic approaches to mitigation and adaptation must be tailored to the context-specific situation and this requires a flexible and participatory planning process to ensure legitimate and salient action, carried out by all important stakeholders. DISTENDER will develop a set of multi-driver qualitative and quantitative socio-economic-climate scenarios through a facilitated participatory process that integrates bottom-up knowledge and locally-relevant drivers with top-down information from the global European Shared Socioeconomic Pathways (SSPs) and downscaled Representative Concentration Pathways (RCPs) from IPCC. A cross-sectorial and multi-scale impact assessment modelling toolkit will be developed to analyse the complex interactions over multiple sectors, including an economic evaluation framework. The economic impact of the different efforts will be analyse, including damage claim settlement and how do sectoral activity patterns change under various scenarios considering indirect and cascading effects. It is an innovative project combining three key concepts: cross-scale, integration/harmonization and robustness checking. DISTENDER will follow a pragmatic approach applying methodologies and toolkits across a range of European case studies (six core case studies and five followers) that reflect a cross-section of the challenges posed by CC adaptation and mitigation. The knowledge generated by DISTENDER will be offered by a Decision Support System (DSS) which will include guidelines, manuals, easy-to-use tools and experiences from the application of the cases studies.